The purpose of the present study was to compare propofol, newly introduced anesthetic agnet, ( thiopental as to the characteristics of induction ( recovery as well as the safety of both agents.
Fifty patients who presented for termination of pregnance were allocated at random to receive either propofor 2mg/kg IV or thiopental 4mg/kg IV. In addition all patients recevied fentanyl, 1(g/kg IV, one minute befor the induction. Repeated bolus
doses
of either propofol 20mg or thiopental 50mg were given, if the patient respond to surgical stimulation by moving.
@ES The result were as follows.
@EN 1)Both propofol and thiopental produced smooth and rapid induction, but caused significant respiratory depression.
2) There was more cardiovascular depression with propofol than with thiopental.
3) Postoperative recovery(time to ambulation) was faster with propofol than with thiopental (36.5(1.4 vs 72.9(5.1 min, p<0.001).
4) Propofol was associated with less side effects(Nausea, vomithing, and dizziness) than thiopental.
These results suggest 1) that propofol has significant advantage over thiopental in outpatient surgery, where early ambulation and discharge is desirable, and 2) that both propofol and thicpental shold be administered by expert anesthesiologist
only
when ventiatory assistant device with oxygen is immediately available.
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